For over 25 years, the psychologist Lisa Damour has been helping teens and their families navigate adolescence in her clinical practice, in her research and in best-selling books like “Untangled: Guiding Teenage Girls Through the Seven Transitions Into Adulthood.”

This moment in time, she says, is like no other.

According to a report released last week by the Centers for Disease Control and Prevention, 42 percent of U.S. high schoolers experienced persistent feelings of sadness or hopelessness in 2021, while 22 percent seriously considered attempting suicide. Adolescent girls, as well as lesbian, gay and bisexual youth, are struggling the most, but boys and teens in every racial and ethnic group also reported worsening symptoms.